mda-7
INGN 241 uses the mda-7 gene, a tumor suppressor that, like p53, induces cell death, or apoptosis, in many types of cancer. In addition to its known activity as a tumor suppressor, the protein produced by the mda-7 gene is secreted and may also stimulate the body's immune system to kill metastatic tumor cells and to protect the body against cancer. This offers an advantage in treating various cancers because it may attack cancer using two different mechanisms. The mda-7 gene acts as a cytokine, or immune system modulator, and is also known as interleukin-24, or IL-24.
| Cancer Indication | Status |
| Head and Neck (combined with radiation therapy) |  |
| Melanoma |  |
| Other solid tumors | |
| Pancreatic |  |
| Breast | |
** We hold the worldwide commercial rights to the product candidates related to each of these programs.
